Immunolocalization of Nestin-Positive Cells in Islets of WNIN-Obese Rats: Implication in Obesity and Acute Pancreatitis

Himadri Singh, Vijayalakshmi Venkatesan

Abstract


Background: WNIN-obese rats are novel animal model to study metabolic syndrome. The islets of WNIN-obese rats have increased pancreatic inflammation and stress. The role of nestin in obesity and acute pancreatitis is not clear.

Methods: Our present study demonstrated presence of nestin in the islets of WNIN-obese rats as well as lean counterpart, when induced with acute pancreatitis.

Results: Interestingly, nestin was localized in islets of WNIN-obese rats, but was absent in islets of control rats.

Conclusion: The localization of nestin may have functional significance in obesity and acute pancreatitis as the nestin-positive stem cells may lead to islet adaptation in pancreatic stress and inflammation.




Cell Mol Med Res. 2023;1(2):51-55
doi: https://doi.org/10.14740/cmmr40

Keywords


Islets; WNIN-obese rats; Nestin; Animal model

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